Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying Tweezer mechanism has not been fully elucidated.We found that the sensitivity of ATRTs to EZH2 inhibition (EZH2i) is associated with the viral mimicry response.Unlike other epigenetic therapies targeting

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Review of Miniature Refrigeration System

Benefit from the progress of manufacturing technology Chocolate Tools and the improvement of heat and mass transfer theory, refrigeration systems have been developing towards miniaturization and portability.This paper introduces three kinds of main refrigeration systems: vapor compression refrigeration, semiconductor refrigeration and absorption re

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Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration

Three-dimensional (3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However, its osseointegration capacity needs to be further improved, and related methods are inadequate, especially lacking customized surface treatment technology.Consequently, we aimed to design an omnidirectional radiator based on

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Tutor system in educational practice in Great Britain

Introduction: an Important task of national pedagogy is related to the understanding and analysis of the experience of educational systems of other countries that have a centuries-old pedagogical.The aim is to evaluate and use the most successful and effective developments of domestic pedagogy.The experience of the UK is leading in relation to the

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